Obsidian Therapeutics, Inc., is a biotechnology company dedicated to the development of next-generation cell and gene therapies with pharmacologic operating systems.

Obsidian has developed a suite of platform technologies that allow for exquisite control of protein activity in cells, thereby enabling tunable cell and gene therapies. The technological foundation of Obsidian’s approach is the use of destabilizing domains (DD), pioneered by Obsidian’s scientific founder, Professor Thomas Wandless, a leading researcher in chemical and systems biology. The system is composed of two parts – a synthetic biological cassette that is installed in the gene vector and a small-molecule drug that controls the activity of the cassette. Obsidian’s cassettes are controllable with readily-available, non-immunosuppressive, FDA-approved small-molecule medicines.